@iwashyna.bsky.social I really enjoyed this New Yorker profile of Butler last year; you might too: www.newyorker.com/magazine/202…
\nJust an incredible academic career through and through
@iwashyna.bsky.social This might be my most firmly-held belief
\n","url":"https://bsky.app/profile/did:plc:q45c5rdv5ldprle5wihibigy/post/3lsepi3qrlc2h","date_published":"2025-06-24T18:18:48+00:00","author":{"name":"Matthew Pappas","url":"https://mattpappas.com","avatar":"https://cdn.micro.blog/photos/96/https%3A%2F%2Favatars.micro.blog%2Favatars%2F2025%2F22%2F1678638.jpg","_microblog":{"username":"mattpappas"}},"_microblog":{"date_relative":"2025-06-24 18:18","date_timestamp":1750789128,"is_favorite":false,"is_bookmark":false,"is_deletable":false,"is_conversation":true,"is_linkpost":false,"is_mention":true}},{"id":"65409856","content_html":"@samirshahmd.bsky.social That is an absolutely astonishing piece of writing. My goodness
\n","url":"https://bsky.app/profile/did:plc:q45c5rdv5ldprle5wihibigy/post/3lq6seknii226","date_published":"2025-05-27T23:04:09+00:00","author":{"name":"Matthew Pappas","url":"https://mattpappas.com","avatar":"https://cdn.micro.blog/photos/96/https%3A%2F%2Favatars.micro.blog%2Favatars%2F2025%2F22%2F1678638.jpg","_microblog":{"username":"mattpappas"}},"_microblog":{"date_relative":"2025-05-27 23:04","date_timestamp":1748387049,"is_favorite":false,"is_bookmark":false,"is_deletable":false,"is_conversation":true,"is_linkpost":false,"is_mention":true}},{"id":"63210046","content_html":"If you struggle to understand what things cost in healthcare, well, (1) you’re not alone, and (2) I wrote a review that might be of interest to you:
\nauthors.elsevier.com/a/1k%7ECo…
\n","summary":"","url":"https://mattpappas.com/2025/04/28/if-you-struggle-to-understand.html","date_published":"2025-04-28T22:43:38+00:00","author":{"name":"Matthew Pappas","url":"https://mattpappas.com","avatar":"https://cdn.micro.blog/photos/96/https%3A%2F%2Favatars.micro.blog%2Favatars%2F2025%2F22%2F1678638.jpg","_microblog":{"username":"mattpappas"}},"_microblog":{"date_relative":"2025-04-28 22:43","date_timestamp":1745880218,"is_favorite":false,"is_bookmark":false,"is_deletable":false,"is_conversation":false,"is_linkpost":false,"is_mention":false,"note":"","syndication":["https://mastodon.social/@mattpappas/114418006144715159","https://bsky.app/profile/did:plc:q45c5rdv5ldprle5wihibigy/post/3lnvtpaef6l2d"]}},{"id":"57424394","content_html":"@mattpappas.bsky.social My thanks to my coauthors, to the folks who critiqued the paper and earlier versions of the analysis, and the two folks who got me started on this project, Andy Auerbach and the late David Meyers. (9/9)
\n","url":"https://bsky.app/profile/did:plc:q45c5rdv5ldprle5wihibigy/post/3lhyxybtth22o","date_published":"2025-02-12T20:07:08+00:00","author":{"name":"Matthew Pappas","url":"https://mattpappas.com","avatar":"https://cdn.micro.blog/photos/96/https%3A%2F%2Favatars.micro.blog%2Favatars%2F2025%2F22%2F1678638.jpg","_microblog":{"username":"mattpappas"}},"_microblog":{"date_relative":"2025-02-12 20:07","date_timestamp":1739390828,"is_favorite":false,"is_bookmark":false,"is_deletable":false,"is_conversation":true,"is_linkpost":false,"is_mention":true}},{"id":"57424395","content_html":"@mattpappas.bsky.social We estimated just one of the downstream harms of broad-spectrum antibiotics. But I hope this approach–trying to rigorously estimate harms for therapies that don’t have RCTs, rather than taking associations at face value–can help us be smarter about lots of treatments we use in the hospital. (8/9)
\n","url":"https://bsky.app/profile/did:plc:q45c5rdv5ldprle5wihibigy/post/3lhyxwukaq22o","date_published":"2025-02-12T20:06:21+00:00","author":{"name":"Matthew Pappas","url":"https://mattpappas.com","avatar":"https://cdn.micro.blog/photos/96/https%3A%2F%2Favatars.micro.blog%2Favatars%2F2025%2F22%2F1678638.jpg","_microblog":{"username":"mattpappas"}},"_microblog":{"date_relative":"2025-02-12 20:06","date_timestamp":1739390781,"is_favorite":false,"is_bookmark":false,"is_deletable":false,"is_conversation":true,"is_linkpost":false,"is_mention":true}},{"id":"57424396","content_html":"@mattpappas.bsky.social To my surprise, this analysis suggests that IV vancomycin is maybe the antibiotic that most increases risk of hospital-onset CDI. I’m not entirely sure why that should be, and hope smarter microbiologists can pick up that thread from here. (7/9)
\n","url":"https://bsky.app/profile/did:plc:q45c5rdv5ldprle5wihibigy/post/3lhyxv3qyf22o","date_published":"2025-02-12T20:05:21+00:00","author":{"name":"Matthew Pappas","url":"https://mattpappas.com","avatar":"https://cdn.micro.blog/photos/96/https%3A%2F%2Favatars.micro.blog%2Favatars%2F2025%2F22%2F1678638.jpg","_microblog":{"username":"mattpappas"}},"_microblog":{"date_relative":"2025-02-12 20:05","date_timestamp":1739390721,"is_favorite":false,"is_bookmark":false,"is_deletable":false,"is_conversation":true,"is_linkpost":false,"is_mention":true}},{"id":"57424397","content_html":"@mattpappas.bsky.social Patients in shock are very likely to get antibiotics, and completely stable patients are not very likely to get antibiotics. (That’s appropriate!) Our approach should approximate a pragmatic RCT where, when it isn’t so clear, we flip a coin. (6/9)
\n","url":"https://bsky.app/profile/did:plc:q45c5rdv5ldprle5wihibigy/post/3lhyxuqovdc2o","date_published":"2025-02-12T20:05:10+00:00","author":{"name":"Matthew Pappas","url":"https://mattpappas.com","avatar":"https://cdn.micro.blog/photos/96/https%3A%2F%2Favatars.micro.blog%2Favatars%2F2025%2F22%2F1678638.jpg","_microblog":{"username":"mattpappas"}},"_microblog":{"date_relative":"2025-02-12 20:05","date_timestamp":1739390710,"is_favorite":false,"is_bookmark":false,"is_deletable":false,"is_conversation":true,"is_linkpost":false,"is_mention":true}},{"id":"57424399","content_html":"@mattpappas.bsky.social Second, we used a causal inference observational design, emulating a hypothetical trial that would have taken patients where it wasn’t clear whether to give an antibiotic or not and randomized them to one of those two conditions. (5/9)
\n","url":"https://bsky.app/profile/did:plc:q45c5rdv5ldprle5wihibigy/post/3lhyxttdyfs2o","date_published":"2025-02-12T20:04:39+00:00","author":{"name":"Matthew Pappas","url":"https://mattpappas.com","avatar":"https://cdn.micro.blog/photos/96/https%3A%2F%2Favatars.micro.blog%2Favatars%2F2025%2F22%2F1678638.jpg","_microblog":{"username":"mattpappas"}},"_microblog":{"date_relative":"2025-02-12 20:04","date_timestamp":1739390679,"is_favorite":false,"is_bookmark":false,"is_deletable":false,"is_conversation":true,"is_linkpost":false,"is_mention":true}},{"id":"57424400","content_html":"@mattpappas.bsky.social My coauthors and I estimated that by doing a few things. First, we used a cohort of patients admitted for COVID in the first wave (before vaccinnation). All these patients were admitted with a viral infection, so there shouldn’t be relationships between antibiotic receipt and later outcomes. (4/9)
\n","url":"https://bsky.app/profile/did:plc:q45c5rdv5ldprle5wihibigy/post/3lhyxte36sk2n","date_published":"2025-02-12T20:04:23+00:00","author":{"name":"Matthew Pappas","url":"https://mattpappas.com","avatar":"https://cdn.micro.blog/photos/96/https%3A%2F%2Favatars.micro.blog%2Favatars%2F2025%2F22%2F1678638.jpg","_microblog":{"username":"mattpappas"}},"_microblog":{"date_relative":"2025-02-12 20:04","date_timestamp":1739390663,"is_favorite":false,"is_bookmark":false,"is_deletable":false,"is_conversation":true,"is_linkpost":false,"is_mention":true}},{"id":"57423861","content_html":"@mattpappas.bsky.social And some patients clearly need broad-spectrum antibiotics! It would be nice if we knew how much harm those broad-spectrum antibiotics caused, not what harm they were associated with. (3/9)
\n","url":"https://bsky.app/profile/did:plc:q45c5rdv5ldprle5wihibigy/post/3lhyxqpsxj22n","date_published":"2025-02-12T20:02:55+00:00","author":{"name":"Matthew Pappas","url":"https://mattpappas.com","avatar":"https://cdn.micro.blog/photos/96/https%3A%2F%2Favatars.micro.blog%2Favatars%2F2025%2F22%2F1678638.jpg","_microblog":{"username":"mattpappas"}},"_microblog":{"date_relative":"2025-02-12 20:02","date_timestamp":1739390575,"is_favorite":false,"is_bookmark":false,"is_deletable":false,"is_conversation":true,"is_linkpost":false,"is_mention":true}},{"id":"57423862","content_html":"@mattpappas.bsky.social Antimicrobials are clearly associated with C. difficile, but that association is highly confounded. (To give one example, we test for C. diff based on loose stools, but loose stools are also a benign side effect of antibiotics.) (2/9)
\n","url":"https://bsky.app/profile/did:plc:q45c5rdv5ldprle5wihibigy/post/3lhyxqe43g22n","date_published":"2025-02-12T20:02:42+00:00","author":{"name":"Matthew Pappas","url":"https://mattpappas.com","avatar":"https://cdn.micro.blog/photos/96/https%3A%2F%2Favatars.micro.blog%2Favatars%2F2025%2F22%2F1678638.jpg","_microblog":{"username":"mattpappas"}},"_microblog":{"date_relative":"2025-02-12 20:02","date_timestamp":1739390562,"is_favorite":false,"is_bookmark":false,"is_deletable":false,"is_conversation":true,"is_linkpost":false,"is_mention":true}},{"id":"57406043","content_html":"I’m delighted to share a new article, Impact of empiric antibiotics on risk of Clostridioides difficile, now published in Antimicrobial Stewardship & Healthcare Epidemiology (ASHE): doi.org/10.1017/a…\n\nAntimicrobials are clearly associated with C. difficile, but that association is highly confounded. (To g... mattpappas.com","summary":"","url":"https://mattpappas.com/2025/02/12/im-delighted-to-share-a.html","date_published":"2025-02-12T16:09:49+00:00","author":{"name":"Matthew Pappas","url":"https://mattpappas.com","avatar":"https://cdn.micro.blog/photos/96/https%3A%2F%2Favatars.micro.blog%2Favatars%2F2025%2F22%2F1678638.jpg","_microblog":{"username":"mattpappas"}},"_microblog":{"date_relative":"2025-02-12 16:09","date_timestamp":1739376589,"is_favorite":false,"is_bookmark":false,"is_deletable":false,"is_conversation":false,"is_linkpost":false,"is_mention":false,"note":"","syndication":[]}},{"id":"57406004","content_html":"@samirshahmd.bsky.social I’m here! For now I really only post when I have a new paper to share
\n","url":"https://bsky.app/profile/did:plc:q45c5rdv5ldprle5wihibigy/post/3lanbrizav22g","date_published":"2024-11-11T02:34:00+00:00","author":{"name":"Matthew Pappas","url":"https://mattpappas.com","avatar":"https://cdn.micro.blog/photos/96/https%3A%2F%2Favatars.micro.blog%2Favatars%2F2025%2F22%2F1678638.jpg","_microblog":{"username":"mattpappas"}},"_microblog":{"date_relative":"2024-11-11 02:34","date_timestamp":1731292440,"is_favorite":false,"is_bookmark":false,"is_deletable":false,"is_conversation":true,"is_linkpost":false,"is_mention":true}},{"id":"57406005","content_html":"@iwashyna.bsky.social Oh, okay. I think I probably wasn’t very helpful here, then!
\n","url":"https://bsky.app/profile/did:plc:q45c5rdv5ldprle5wihibigy/post/3l4ekhxi2st2c","date_published":"2024-09-17T17:34:59+00:00","author":{"name":"Matthew Pappas","url":"https://mattpappas.com","avatar":"https://cdn.micro.blog/photos/96/https%3A%2F%2Favatars.micro.blog%2Favatars%2F2025%2F22%2F1678638.jpg","_microblog":{"username":"mattpappas"}},"_microblog":{"date_relative":"2024-09-17 17:34","date_timestamp":1726594499,"is_favorite":false,"is_bookmark":false,"is_deletable":false,"is_conversation":true,"is_linkpost":false,"is_mention":true}},{"id":"57406006","content_html":"@iwashyna.bsky.social I have a PS5. I meant to suggest that you might need to downscale some graphics settings, since even a PS5 is sometimes pushed to its limit.
\nBut I have no knowledge of PS4 settings, and so can’t offer specifics on what it would look like–the PS5 is the only non-Nintendo console I’ve ever owned!
\n","url":"https://bsky.app/profile/did:plc:q45c5rdv5ldprle5wihibigy/post/3l4ejpqmrkk2m","date_published":"2024-09-17T17:21:27+00:00","author":{"name":"Matthew Pappas","url":"https://mattpappas.com","avatar":"https://cdn.micro.blog/photos/96/https%3A%2F%2Favatars.micro.blog%2Favatars%2F2025%2F22%2F1678638.jpg","_microblog":{"username":"mattpappas"}},"_microblog":{"date_relative":"2024-09-17 17:21","date_timestamp":1726593687,"is_favorite":false,"is_bookmark":false,"is_deletable":false,"is_conversation":true,"is_linkpost":false,"is_mention":true}},{"id":"57406007","content_html":"@iwashyna.bsky.social I’ll add that I had to turn off ray tracing (and maybe some other graphics-intensive setting? not sure) so that my PS5 could keep up without getting all choppy
\n","url":"https://bsky.app/profile/did:plc:q45c5rdv5ldprle5wihibigy/post/3l4ef5kpsgr2h","date_published":"2024-09-17T15:59:42+00:00","author":{"name":"Matthew Pappas","url":"https://mattpappas.com","avatar":"https://cdn.micro.blog/photos/96/https%3A%2F%2Favatars.micro.blog%2Favatars%2F2025%2F22%2F1678638.jpg","_microblog":{"username":"mattpappas"}},"_microblog":{"date_relative":"2024-09-17 15:59","date_timestamp":1726588782,"is_favorite":false,"is_bookmark":false,"is_deletable":false,"is_conversation":true,"is_linkpost":false,"is_mention":true}},{"id":"57406008","content_html":"@iwashyna.bsky.social Probably David Swensen’s “Unconventional Success”. Swensen apparently managed the Yale endowment, but does a really nice job laying out modern portfolio theory on the scale of an individual investor: Unconventional Success: A… www.amazon.com/dp/074322838…
\n","url":"https://bsky.app/profile/did:plc:q45c5rdv5ldprle5wihibigy/post/3kvdbsqpaqk2n","date_published":"2024-06-20T03:30:57+00:00","author":{"name":"Matthew Pappas","url":"https://mattpappas.com","avatar":"https://cdn.micro.blog/photos/96/https%3A%2F%2Favatars.micro.blog%2Favatars%2F2025%2F22%2F1678638.jpg","_microblog":{"username":"mattpappas"}},"_microblog":{"date_relative":"2024-06-20 03:30","date_timestamp":1718854257,"is_favorite":false,"is_bookmark":false,"is_deletable":false,"is_conversation":true,"is_linkpost":false,"is_mention":true}}]}